Scientist I / II, Small Molecule Drug Development (Predictive Dissolution)

Job Description

Biogen is seeking a highly motivated and creative candidate to fill a Scientist I/II position within its Small Molecule Drug Development organization.

The successful candidate will perform activities with an emphasis on the design and development of predictive in vitro methodologies and the characterization of prototype formulations to support small molecule programs from preclinical to commercial stage. This position is ideally suited for someone interested in rethinking the role of biopharmaceutics within pharmaceutical development. Our team is empowered like a startup, but with the resources of a large company.  We succeed by collaborating strategically with our partners inside and external to Biogen.

Responsibilities include (but are not limited to):

1)    Design, develop and perform predictive in vitro methodologies (i.e., dissolution, etc.)  to assess in vivo performance of various formulation types in order to develop a more competitive drug product and enhance patience compliance

2)    Support drug product formulation and process development including characterization of drug substance, prototype formulations, process intermediates, and finished products.

Qualifications

Education & Experience Requirements:

Scientist I:

• M.S. degree in Pharmaceutical Sciences, Pharmaceutics, analytical chemistry or related fields with 3-4 years of relevant experience
• B.S. degree with 4-6 years of relevant experience

Scientist II:

• Ph.D. in Pharmaceutical Sciences, Pharmaceutics, analytical chemistry or related fields with 0 - 4 years’ experience in pharmaceutical or biotech settings.
• M.S. degree with 4+ to 6 years of relevant experience
• B.S. degree with 6+ to 8 years of relevant experience  

Preferred Requirements:

• Background in Biopharmaceutics, Pharmaceutics, Pharmaceutical Sciences, or related science. Strong lab-based knowledge of predictive dissolution, IVIVC and drug product characterization.
• Experience on the design of predictive in vitro methodologies via compendial dissolution apparatuses (USP apparatus I-IV) or non-compendial dissolution apparatuses to inform formulation development are highly desirable
• Experience/knowledge in formulation, drug delivery, pharmacokinetics, absorption modeling, DMPK and physiology are highly desirable
• Rich hands-on experience with GastroPlus, Simcyp, WinNonlin, etc. are highly desirable
• Strong problem-solving and troubleshooting skills, strong capabilities in experimental design and execution, as well ability to work independently are essential.
• Strong verbal and written communication skills, strong interpersonal skills and the ability to serve as a team member/leader in an environment where individual initiative, collaboration and accountability are valued.
• Proven skills and ability to work collaboratively with both internal and external partners

Additional Information

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.